header banner
Default

The effectiveness and mechanism of 0 point05 percent cyclosporine eye drops (II) monotherapy for allergic conjunctivitis-associated dry eye are being investigated


Table of Contents
  • Craig JP, Nichols KK, Akpek EK, Caffery B, Dua HS, Joo C-K, et al. TFOS DEWS II definition and classification report. Ocul Surf. 2017;15:276–83.

    Article  PubMed  Google Scholar 

  • Villani E, Rabbiolo G, Nucci P. Ocular allergy as a risk factor for dry eye in adults and children. Curr Opin Allergy Clin Immunol. 2018;18:398–403.

    Article  PubMed  Google Scholar 

  • Leonardi A, Modugno RL, Salami E. Allergy and dry eye disease. Ocul Immunol Inflamm. 2021;29:1168–76.

    Article  PubMed  Google Scholar 

  • Dominick LO, Justin TK, Jennifer H, Eric B, Milton MH. Prevalence of allergic conjunctivitis, ocular surface disease subtypes, and mixed disease. Invest Ophthalmol Vis Sci. 2014;55:2751.

    Google Scholar 

  • Akasaki Y, Inomata T, Sung J, Nakamura M, Kitazawa K, Shih KC, et al. Prevalence of comorbidity between dry eye and allergic conjunctivitis: a systematic review and meta-analysis. J Clin Med. 2022;11:3643.

    Article  PubMed Central  PubMed  Google Scholar 

  • Chen L, Pi L, Fang J, Chen X, Ke N, Liu Q. High incidence of dry eye in young children with allergic conjunctivitis in Southwest China. Acta Ophthalmol. 2016;94:e727–30.

    Article  PubMed  Google Scholar 

  • Dupuis P, Prokopich CL, Hynes A, Kim H. A contemporary look at allergic conjunctivitis. Allergy Asthma Clin Immunol. 2020;16:5.

    Article  PubMed Central  PubMed  Google Scholar 

  • Nye M, Rudner S, Bielory L. Emerging therapies in allergic conjunctivitis and dry eye syndrome. Expert Opin Pharmacother. 2013;14:1449–65.

    Article  CAS  PubMed  Google Scholar 

  • Nguyen E, Yanes D, Imadojemu S, Kroshinsky D. Evaluation of cyclosporine for the treatment of DRESS syndrome. JAMA Dermatol. 2020;156:704–6.

    Article  PubMed Central  PubMed  Google Scholar 

  • Fauquert J-L. Diagnosing and managing allergic conjunctivitis in childhood: the allergist’s perspective. Pediatr Allergy Immunol. 2019;30:405–14.

    Article  PubMed  Google Scholar 

  • Raizman MB, Hamrah P, Holland EJ, Kim T, Mah FS, Rapuano CJ, et al. Drug-induced corneal epithelial changes. Surv Ophthalmol. 2017;62:286–301.

    Article  PubMed  Google Scholar 

  • Gao M, Zhao L, Liang R, Zhu Q, Zhao Q, Kong X. Evaluation of the efficacy and safety of topical 0.05% cyclosporine eye drops (II) in the treatment of dry eye associated with Primary Sjögren’s Syndrome. Ocul Immunol Inflamm. 2023;31:1662–1668.

  • Labib BA, Chigbu DI. Therapeutic targets in allergic conjunctivitis. Pharm (Basel). 2022;15:547.

    Article  CAS  Google Scholar 

  • Bao J, Tian L, Meng Y, Wu B, Wang J, He J, et al. Total IgE in tears accurately reflects the severity and predicts the prognosis of seasonal allergic conjunctivitis. Clin Transl Allergy. 2022;12:e12139.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Lin X, Huang J-F, Liu Z. Large scale, prospective, multicenter, clinical evaluation of point-of-care lymphotoxin alpha (LTA) test in dry eye disease. Investig Ophthalmol Vis Sci. 2020;61:116.

    Google Scholar 

  • Suárez-Cortés T, Merino-Inda N, Benitez-Del-Castillo JM. Tear and ocular surface disease biomarkers: a diagnostic and clinical perspective for ocular allergies and dry eye disease. Exp Eye Res. 2022;221:109121.

    Article  PubMed  Google Scholar 

  • Rhim JW, Eom Y, Yoon EG, Park SY, Choi Y, Song JS, et al. Efficacy of a 0.05% cyclosporine a topical nanoemulsion in dry eyes with obstructive meibomian gland dysfunction. Jpn J Ophthalmol. 2022;66:254–63.

    Article  CAS  PubMed  Google Scholar 

  • Asian Dry Eye Association China Chapter. Chinese expert consensus on dry eye: definition and classification (2020). Chin J Ophthalmol. 2020;56:418–22.

    Google Scholar 

  • Nelson JD, Havener VR, Cameron JD. Cellulose acetate impressions of the ocular surface. Dry eye states. Arch Ophthalmol. 1983;101:1869–72.

    Article  CAS  PubMed  Google Scholar 

  • Patel D, Wairkar S. Recent advances in cyclosporine drug delivery: challenges and opportunities. Drug Deliv Transl Res. 2019;9:1067–81.

    Article  CAS  PubMed  Google Scholar 

  • Prabhasawat P, Tesavibul N, Mahawong W. A randomized double-masked study of 0.05% cyclosporine ophthalmic emulsion in the treatment of meibomian gland dysfunction. Cornea. 2012;31:1386–93.

    Article  PubMed  Google Scholar 

  • Leong E, Pang Z, Stadnyk AW, Lin TJ. Calcineurin Aα contributes to IgE-dependent mast-cell mediator secretion in allergic inflammation. J Innate Immun. 2022;14:320–34.

    Article  CAS  PubMed  Google Scholar 

  • Kam KW, Chen LJ, Wat N, Young AL. Topical olopatadine in the treatment of allergic conjunctivitis: a systematic review and meta-analysis. Ocul Immunol Inflamm. 2017;25:663–77.

    Article  PubMed  Google Scholar 

  • Vichyanond P, Kosrirukvongs P. Use of cyclosporine A and tacrolimus in treatment of vernal keratoconjunctivitis. Curr Allergy Asthma Rep. 2013;13:308–14.

    Article  CAS  PubMed  Google Scholar 

  • Villareal AL, Farley W, Pflugfelder SC. Effect of topical ophthalmic epinastine and olopatadine on tear volume in mice. Eye Contact Lens. 2006;32:272–6.

    Article  PubMed  Google Scholar 

  • Wan KH-N, Chen LJ, Rong SS, Pang CP, Young AL. Topical cyclosporine in the treatment of allergic conjunctivitis: a meta-analysis. Ophthalmology. 2013;120:2197–203.

    Article  PubMed  Google Scholar 

  • Leonardi A, Messmer EM, Labetoulle M, Amrane M, Garrigue J-S, Ismail D, et al. Efficacy and safety of 0.1% ciclosporin A cationic emulsion in dry eye disease: a pooled analysis of two double-masked, randomised, vehicle-controlled phase III clinical studies. Br J Ophthalmol. 2019;103:125–31.

    Article  PubMed  Google Scholar 

  • Cui H, Liu F, Fang Y, Wang T, Yuan B, Ma C. Neuronal FcεRIα directly mediates ocular itch via IgE-immune complex in a mouse model of allergic conjunctivitis. J Neuroinflamm. 2022;19:55.

    Article  CAS  Google Scholar 

  • Ambroziak AM, Szaflik J, Szaflik JP, Ambroziak M, Witkiewicz J, Skopiński P. Immunomodulation on the ocular surface: a review. Cent Eur J Immunol. 2016;41:195–208.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Hashimoto T, Mishra SK, Olivry T, Yosipovitch G. Periostin, an emerging player in itch sensation. J Invest Dermatol. 2021;141:2338–43.

    Article  CAS  PubMed  Google Scholar 

  • Izuhara K, Nunomura S, Nanri Y, Ono J, Takai M, Kawaguchi A. Periostin: an emerging biomarker for allergic diseases. Allergy. 2019;74:2116–28.

    Article  PubMed  Google Scholar 

  • García-Posadas L, Hodges RR, Diebold Y, Dartt DA. Context-dependent regulation of conjunctival goblet cell function by allergic mediators. Sci Rep. 2018;8:12162.

    Article  PubMed Central  PubMed  Google Scholar 

  • Yoon K-C, Jeong I-Y, Park Y-G, Yang S-Y. Interleukin-6 and tumor necrosis factor-alpha levels in tears of patients with dry eye syndrome. Cornea. 2007;26:431–7.

    Article  PubMed  Google Scholar 

  • Keller C, Hellsten Y, Steensberg A, Pedersen BK. Differential regulation of IL-6 and TNF-alpha via calcineurin in human skeletal muscle cells. Cytokine. 2006;36:141–7.

    Article  CAS  PubMed  Google Scholar 

  • Cook EB, Stahl JL, Barney NP, Graziano FM. Olopatadine inhibits TNF-alpha release from human conjunctival mast cells. Ann Allergy Asthma Immunol. 2000;84:504–8.

    Article  CAS  PubMed  Google Scholar 

  • Nakae S, Suto H, Kakurai M, Sedgwick JD, Tsai M, Galli SJ. Mast cells enhance T cell activation: Importance of mast cell-derived TNF. Proc Natl Acad Sci USA. 2005;102:6467–72.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Kang MJ, Kim HS, Kim MS, Kim EC. The Correlation between matrix metalloproteinase-9 point-of-care immunoassay, tear film osmolarity, and ocular surface parameters. J Ophthalmol. 2022;2022:6132016.

    Article  PubMed Central  PubMed  Google Scholar 

  • Chen H, Chen H, Liang L, Zhong Y, Liang Y, Yu Y, et al. Evaluation of tear protein markers in dry eye disease with different lymphotoxin-alpha expression levels. Am J Ophthalmol. 2020;217:198–211.

    Article  CAS  PubMed  Google Scholar 

  • Davies K, Mirza K, Tarn J, Howard-Tripp N, Bowman SJ, Lendrem D, et al. Fatigue in primary Sjögren’s syndrome (pSS) is associated with lower levels of proinflammatory cytokines: a validation study. Rheumatol Int. 2019;39:1867–73.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Ma J, Li C, Zhao Y, Shen Z, Hu B, Peng R, et al. Ophthalmic manifestations are associated with reduced tear lymphotoxin-α levels in chronic ocular graft-versus-host disease. BMC Ophthalmol. 2022;22:18.

    Article  PubMed Central  PubMed  Google Scholar 

  • Messmer EM, von Lindenfels V, Garbe A, Kampik A. Matrix metalloproteinase 9 testing in dry eye disease using a commercially available point-of-care immunoassay. Ophthalmology. 2016;123:2300–8.

    Article  PubMed  Google Scholar 

  • Park JY, Kim BG, Kim JS, Hwang JH. Matrix metalloproteinase 9 point-of-care immunoassay result predicts response to topical cyclosporine treatment in dry eye disease. Transl Vis Sci Technol. 2018;7:31.

    Article  PubMed Central  PubMed  Google Scholar 

  • Kuprash DV, Boitchenko VE, Yarovinsky FO, Rice NR, Nordheim A, Rühlmann A, et al. Cyclosporin A blocks the expression of lymphotoxin alpha, but not lymphotoxin beta, in human peripheral blood mononuclear cells. Blood. 2002;100:1721–7.

    CAS  PubMed  Google Scholar 

  • Sources


    Article information

    Author: Misty Turner

    Last Updated: 1700158803

    Views: 1085

    Rating: 4.6 / 5 (108 voted)

    Reviews: 95% of readers found this page helpful

    Author information

    Name: Misty Turner

    Birthday: 1932-11-03

    Address: 425 Shaw Haven, Adrianland, WI 04921

    Phone: +4863596514674197

    Job: Event Planner

    Hobby: Motorcycling, Origami, Aquarium Keeping, Robotics, Photography, Gardening, Surfing

    Introduction: My name is Misty Turner, I am a risk-taking, Adventurous, variegated, valuable, artistic, accomplished, apt person who loves writing and wants to share my knowledge and understanding with you.